Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture

J. A. Levy, A. Landay, E. T. Lennette

Research output: Contribution to journalArticlepeer-review

Abstract

The SF strain of human herpesvirus 6 (HHV-6(SF)) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.

Original languageEnglish (US)
Pages (from-to)2362-2364
Number of pages3
JournalJournal of Clinical Microbiology
Volume28
Issue number10
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)

Fingerprint

Dive into the research topics of 'Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture'. Together they form a unique fingerprint.

Cite this