TY - JOUR
T1 - Human exfoliated deciduous teeth stem cells
T2 - Features and therapeutic effects on neurogenerative and hepatobiliary-pancreatic diseases
AU - Wahab, Nurul W.A.
AU - Guad, Rhanye M.
AU - Subramaniyan, Vetriselvan
AU - Fareez, Ismail M.
AU - Choy, Ker W.
AU - Bonam, Srinivasa R.
AU - Selvaraju, Chandrasekaran
AU - Sim, Maw S.
AU - Gopinath, Subash C.B.
AU - Wu, Yuan S.
N1 - Publisher Copyright:
© 2021 Bentham Science Publishers.
PY - 2021
Y1 - 2021
N2 - Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.
AB - Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.
KW - Diabetes mellitus
KW - Human exfoliated deciduous teeth
KW - Liver diseases
KW - Neurodegenerative disease
KW - Organ transplantation
KW - Pluripotent
KW - Retinal degeneration
KW - SHEDs
KW - Totipotency
UR - http://www.scopus.com/inward/record.url?scp=85114055976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85114055976&partnerID=8YFLogxK
U2 - 10.2174/1574888X15999200918105623
DO - 10.2174/1574888X15999200918105623
M3 - Review article
C2 - 32957893
AN - SCOPUS:85114055976
SN - 1574-888X
VL - 16
SP - 563
EP - 576
JO - Current Stem Cell Research and Therapy
JF - Current Stem Cell Research and Therapy
IS - 5
ER -