Abstract
To comprehend the reduced susceptibitity of HLA-DQ6 transgenic mice in comparison with HLA-DQ8 mice, to experimental autoimmune myasthenia gravis (EAMG), we immunized them with acetylcholine receptor (AChR) and examined in vitro, the proliferative and cytokine responses to AChR. When immunized with AChR and examined for AChR-specific lymphocyte responses to AChR, EAMG-resistant DQ6 mice exhibited significantly reduced in vitro lymphoproliferative and cytokine responses to AChR, compared to DQ8 mice. The differences in susceptibility were not linked to a difference in peptide recognition by AChR-specific lymphocytes. AChR T cell epitope mapping showed that both DQ6 and DQ8 responded to the same epitopes, although to varying degrees. Resistance of DQ6 transgenic mice to EAMG was linked to a dramatic suppression of AChR-specific IFN-γ, IL-2 and IL-10 productions by AChR-primed lymph node cells.
Original language | English (US) |
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Pages (from-to) | 175-180 |
Number of pages | 6 |
Journal | Journal of Autoimmunity |
Volume | 17 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1 2001 |
Externally published | Yes |
Keywords
- Autoimmunity
- Cytokines
- MHC
- Myasthenia gravis
- Transgenic
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology