Abstract
The purpose of this study was to examine the genetic linkage (but not the association) between HLA complex and Weber-Cockayne Subtype of epidermolysis bullosa (EBS-WC). We HLA typed 44 members of three multi-generation families in which 24 members have the clinical evidence of EBS-WC. The patterns of inheritance of various HLA haplotypes and the disease were mathematically analyzed to estimate frequency of recombination (i.e. genetic distance) between HLA complex and the disease by calculating Lod Scores for each family separately as well as all for three families combined. Our results show that only one family had a positive Lod Score. The Lod Scores for the remaining two families as well as the combined Lod Score for all three families were negative. These data suggest that odds are against the genetic linkage between HLA complex and Weber-Cockayne Subtype of epidermolysis bullosa and in favor of independent assortment of the disease and HLA complex.
Original language | English (US) |
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Pages (from-to) | 155-160 |
Number of pages | 6 |
Journal | Journal of Dermatological Science |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - May 1991 |
Externally published | Yes |
Keywords
- Epidermolysis bullosa
- Genetic linkage
- HLA
- Independent assortment
- Inheritance
- Weber-Cockayne
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology