HIV type 1 and cytomegalovirus coinfection in the female genital tract

Nell S. Lurain; Emmanuel S. Robert; Jiahong Xu; Margaret Camarca; Alan Landay; Andrea A. Kovacs; Patricia S. Reichelderfer

doi:10.1086/422533

HIV type 1 and cytomegalovirus coinfection in the female genital tract

Nell S. Lurain, Emmanuel S. Robert, Jiahong Xu, Margaret Camarca, Alan Landay, Andrea A. Kovacs, Patricia S. Reichelderfer

Research output: Contribution to journal › Article › peer-review

Abstract

The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1β and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.

Original language	English (US)
Pages (from-to)	619-623
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	190
Issue number	3
DOIs	https://doi.org/10.1086/422533
State	Published - Aug 1 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/422533

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title = "HIV type 1 and cytomegalovirus coinfection in the female genital tract",

abstract = "The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1β and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.",

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AU - Lurain, Nell S.

AU - Robert, Emmanuel S.

AU - Xu, Jiahong

AU - Camarca, Margaret

AU - Landay, Alan

AU - Kovacs, Andrea A.

AU - Reichelderfer, Patricia S.

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AB - The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1β and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.

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HIV type 1 and cytomegalovirus coinfection in the female genital tract

Abstract

ASJC Scopus subject areas

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