@article{ff1c470be7f14d708a61bacde7c50a8b,
title = "HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter",
abstract = "Despite modern antiretroviral therapy, HIVassociated sensory neuropathy affects over 50% of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatment-resistant complications of HIV disease. The presence and intensity of pain is not fully explained by the degree of peripheral nerve damage, making it unclear why some patients do, and others do not, report pain. To better understand central nervous system contributions to HIV DNP, we performed a cross-sectional analysis of structural magnetic resonance imaging volumes in 241 HIV-infected participants from an observational multi-site cohort study at five US sites (CNS HIV Anti-Retroviral Treatment Effects Research Study, CHAR TER). The association between DNP and the structural imaging outcomes was investigated using both linear and nonlinear (Gaussian Kernel support vector) multivariable regression, controlling for key demographic and clinical variables. Severity of DNP symptoms was correlated with smaller total cerebral cortical gray matter volume (r = -0.24; p =0.004). Understanding the mechanisms for this association between smaller total cortical volumes and DNP may provide insight into HIV DNP chronicity and treatment-resistance.",
keywords = "Cortical volume, HIV distal neuropathic pain, Structural MRI",
author = "Keltner, {John R.} and Christine Fennema-Notestine and Florin Vaida and Dongzhe Wang and Franklin, {Donald R.} and Dworkin, {Robert H.} and Chelsea Sanders and McCutchan, {J. Allen} and Archibald, {Sarah L.} and Miller, {David J.} and George Kesidis and Clint Cushman and Kim, {Sung Min} and Ian Abramson and Taylor, {Michael J.} and Theilmann, {Rebecca J.} and Julaton, {Michelle D.} and Notestine, {Randy J.} and Stephanie Corkran and Mariana Cherner and Duarte, {Nichole A.} and Terry Alexander and Jessica Robinson-Papp and Gelman, {Benjamin B.} and Simpson, {David M.} and Collier, {Ann C.} and Marra, {Christina M.} and Susan Morgello and Greg Brown and Igor Grant and Atkinson, {J. Hampton} and Jernigan, {Terry L.} and Ellis, {Ronald J.}",
note = "Funding Information: This research was supported by awards N01 MH22005, R25-MH081482, HHSN271201000027C, R01 MH079752 and P30 MH0625 from the National Institutes of Health. Disclaimer: The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Government. The authors have no conflicts of interest to disclose. Each author John R. Keltner, Christine Fennema-Notestine, Florin Vaida, Dongzhe Wang, Donald R. Franklin, Robert H. Dworkin, Chelsea Sanders, J. Allen McCutchan, Sarah L. Archibald, David J. Miller, George Kesidis, Clint Cushman, Sung Min Kim, Ian Abramson, Michael J. Taylor, Rebecca J. Theilmann, Michelle D. Julaton, Randy J. Notestine, Stephanie Corkran, Mariana Cherner, Nichole A. Duarte, Terry Alexander, Jessica Robinson-Papp, Benjamin B. Gelman, David M. Simpson, Ann C. Collier, Christina M. Marra, Susan Morgello, Greg Brown, Igor Grant, J. Hampton Atkinson, Terry L. Jernigan and Ronald J. Ellis does not have a financial relationship with the National Institutes of Health.",
year = "2014",
month = jun,
doi = "10.1007/s13365-014-0236-8",
language = "English (US)",
volume = "20",
pages = "209--218",
journal = "Journal of neurovirology",
issn = "1355-0284",
publisher = "Springer New York",
number = "3",
}