High-speed ultrahigh-resolution OCT of bruch's membrane in membranoproliferative glomerulonephritis type 2

Mehreen Adhi; Sarah P. Read; Jonathan J. Liu; James G. Fujimoto; Jay S. Duker

doi:10.3928/23258160-20141118-20

High-speed ultrahigh-resolution OCT of bruch's membrane in membranoproliferative glomerulonephritis type 2

Mehreen Adhi, Sarah P. Read, Jonathan J. Liu, James G. Fujimoto, Jay S. Duker

Research output: Contribution to journal › Article › peer-review

Abstract

Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

Original language	English (US)
Pages (from-to)	614-617
Number of pages	4
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	45
Issue number	6
DOIs	https://doi.org/10.3928/23258160-20141118-20
State	Published - Nov 1 2014
Externally published	Yes

ASJC Scopus subject areas

Surgery
Ophthalmology

Access to Document

10.3928/23258160-20141118-20

Cite this

@article{6eec2583704943c0bd5fec23ac2114ce,

title = "High-speed ultrahigh-resolution OCT of bruch's membrane in membranoproliferative glomerulonephritis type 2",

abstract = "Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.",

author = "Mehreen Adhi and Read, {Sarah P.} and Liu, {Jonathan J.} and Fujimoto, {James G.} and Duker, {Jay S.}",

year = "2014",

month = nov,

day = "1",

doi = "10.3928/23258160-20141118-20",

language = "English (US)",

volume = "45",

pages = "614--617",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

issn = "2325-8160",

publisher = "Slack Incorporated",

number = "6",

}

TY - JOUR

T1 - High-speed ultrahigh-resolution OCT of bruch's membrane in membranoproliferative glomerulonephritis type 2

AU - Adhi, Mehreen

AU - Read, Sarah P.

AU - Liu, Jonathan J.

AU - Fujimoto, James G.

AU - Duker, Jay S.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

AB - Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

UR - http://www.scopus.com/inward/record.url?scp=84918524429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918524429&partnerID=8YFLogxK

U2 - 10.3928/23258160-20141118-20

DO - 10.3928/23258160-20141118-20

M3 - Article

C2 - 25423645

AN - SCOPUS:84918524429

SN - 2325-8160

VL - 45

SP - 614

EP - 617

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

IS - 6

ER -

High-speed ultrahigh-resolution OCT of bruch's membrane in membranoproliferative glomerulonephritis type 2

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this