TY - JOUR
T1 - High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus
AU - Asrani, Priyanka
AU - Aly, Ashraf M.
AU - Jiwani, Amyn K.
AU - Niebuhr, Bruce R.
AU - Christenson, Robert H.
AU - Jain, Sunil K.
N1 - Publisher Copyright:
© 2018, Springer Nature America, Inc.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Objective: To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum. Study design: Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Student t-test, two proportion z-test, and regression analysis. Results: Seventy infants were enrolled. Infants in the hsPDA group had lower gestation and birth weight. Mean hsTnT and NTproBNP levels in the hsPDA group were higher compared to the group without an hsPDA, with levels being 251.54 vs 161.6 pg/ml, p < 0.01 for hsTnT and 18181.02 vs 3149.23 pg/ml, p < 0.001 for NTproBNP. Conclusion: HsPDA leads to increased hsTnT and NTproBNP levels in preterm infants without affecting cardiac function.
AB - Objective: To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum. Study design: Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Student t-test, two proportion z-test, and regression analysis. Results: Seventy infants were enrolled. Infants in the hsPDA group had lower gestation and birth weight. Mean hsTnT and NTproBNP levels in the hsPDA group were higher compared to the group without an hsPDA, with levels being 251.54 vs 161.6 pg/ml, p < 0.01 for hsTnT and 18181.02 vs 3149.23 pg/ml, p < 0.001 for NTproBNP. Conclusion: HsPDA leads to increased hsTnT and NTproBNP levels in preterm infants without affecting cardiac function.
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U2 - 10.1038/s41372-018-0192-x
DO - 10.1038/s41372-018-0192-x
M3 - Article
C2 - 30171214
AN - SCOPUS:85053068273
SN - 0743-8346
VL - 38
SP - 1483
EP - 1489
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -