High risk human papillomavirus at entry to prenatal care and risk of preeclampsia

Mollie McDonnold, Holly Dunn, Ashley Hester, Luis D. Pacheco, Gary D.V. Hankins, George R. Saade, Maged M. Costantine

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Objective To determine the association between high-risk human papillomavirus (HR-HPV) and preeclampsia. Methods Retrospective cohort study of women with HR-HPV at entry to prenatal care compared with those with at least 2 normal pap smears. Preeclampsia was defined by clinical guidelines. Unadjusted and adjusted analyses were performed. Results Three hundred fourteen women with HR-HPV matched with 628 women with normal pap smears. Exposed HR-HPV patients were younger, had lower body mass index, systolic and diastolic blood pressure at entry to care, and more likely to be nulliparous and smokers. Exposed HR-HPV patients were more likely to develop preeclampsia (10.19% vs 4.94%; P =.004; adjusted odds ratio, 2.18; 95% confidence interval, 1.31-3.65). Women with HR-HPV were also more likely to deliver prematurely at less than 37 and less than 35 weeks. Conclusion HR-HPV is associated with an almost 2-fold increased risk of developing preeclampsia. This warrants a larger study, particularly when HPV infection can be prevented with vaccination.

Original languageEnglish (US)
Pages (from-to)138.e1-138.e5
JournalAmerican journal of obstetrics and gynecology
Issue number2
StatePublished - Feb 2014


  • human papilloma virus
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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