High-LET radiation carcinogenesis

R. J.M. Fry; R. L. Ullrich; P. Powers-Risius; E. L. Alpen; E. J. Ainsworth

doi:10.1016/0273-1177(83)90194-1

High-LET radiation carcinogenesis

R. J.M. Fry, R. L. Ullrich, P. Powers-Risius, E. L. Alpen, E. J. Ainsworth

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33 Scopus citations

Abstract

Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20-30 rads.

Original language	English (US)
Pages (from-to)	241-248
Number of pages	8
Journal	Advances in Space Research
Volume	3
Issue number	8
DOIs	https://doi.org/10.1016/0273-1177(83)90194-1
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Aerospace Engineering
Astronomy and Astrophysics
Geophysics
Atmospheric Science
Space and Planetary Science
General Earth and Planetary Sciences

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10.1016/0273-1177(83)90194-1

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title = "High-LET radiation carcinogenesis",

abstract = "Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20-30 rads.",

author = "Fry, {R. J.M.} and Ullrich, {R. L.} and P. Powers-Risius and Alpen, {E. L.} and Ainsworth, {E. J.}",

note = "Funding Information: This research was sponsored jointly by the Office of Health and Environmental Research, U. S. Department of Energy under contract W—7405—eng—26 with the Union Carbide Corporation",

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T1 - High-LET radiation carcinogenesis

AU - Fry, R. J.M.

AU - Ullrich, R. L.

AU - Powers-Risius, P.

AU - Alpen, E. L.

AU - Ainsworth, E. J.

N1 - Funding Information: This research was sponsored jointly by the Office of Health and Environmental Research, U. S. Department of Energy under contract W—7405—eng—26 with the Union Carbide Corporation

PY - 1983

Y1 - 1983

N2 - Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20-30 rads.

AB - Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20-30 rads.

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High-LET radiation carcinogenesis

Abstract

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