Hidden Aspects of Valency in Immune System Regulation

Parimal Samir, Thirumala Devi Kanneganti

Research output: Contribution to journalReview articlepeer-review


Valency can be defined as the number of discrete interactions a biomolecule can engage in. Valency can be critical for function, such as determining whether a molecule acts as a scaffold for assembling large supramolecular complexes or forms a functional dimer. Here, we highlight the importance of the role of valency in regulating immune responses, with a focus on innate immunity. We discuss some of the ways in which valency itself is regulated through transcriptional, post-transcriptional, and post-translational modifications. Finally, we propose that the valency model can be applied at the whole cell level to study differences in individual cell responses with relevance to putative therapeutic applications.

Original languageEnglish (US)
Pages (from-to)1082-1094
Number of pages13
JournalTrends in Immunology
Issue number12
StatePublished - Dec 2019
Externally publishedYes


  • AIM2
  • ASC
  • CASP1
  • DNA sensing
  • IL-18
  • IL-1α
  • IL-1β
  • IRAK4
  • MYD88
  • NLRP3
  • cGAS
  • inflammasome
  • myddosome
  • proinflammatory cytokines
  • pyroptosis
  • stress granules
  • valency

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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