Heterogeneity of response to therapy

Research output: Chapter in Book/Report/Conference proceedingChapter


As noted in prior chapters, US national and international guidelines provide a consistent approach to initial management of asthma, based on easily observed physical and physiologic findings, and a detailed history. From those data, a rational initial therapeutic regimen can be prescribed. In many cases, such therapy results in near complete control of asthma symptoms, restoration of normal lung physiology, and elimination of exacerbations. In fact, such improvement is frequent enough that therapeutic responsiveness to asthma treatments was thought to be nearly universal. However, it is not uncommon for patients to return with incomplete, or even trivial improvement in these clinical metrics of control (Langmack and Martin Curr Opin Pulm Med 16:13-18, 2010). In this chapter, we review the current literature on the variability of response to commonly used therapeutic agents in asthma.

Original languageEnglish (US)
Title of host publicationHeterogeneity in Asthma
PublisherSpringer New York LLC
Number of pages6
ISBN (Print)9781461486022
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Asthma
  • Heterogeneity
  • IL-13
  • Inhaled steroid
  • Molecular phenotype
  • Montelukast
  • Periostin
  • Predictive phenotype
  • Therapeutic response

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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