Hepatocellular ultrastructure in asymptomatic hepatitis B antigenemia

S. C. Sun, K. E. Anderson, C. P. Hsu, S. L. Kau

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Liver tissue from 21 Chinese military recruits with hepatitis B (HB) antigenemia was examined by electron microscopy. Fine structural abnormalities of the endoplasmic reticulum, mitochondria, and bile canaliculi were frequently present. Nuclear abnormalities were not prominent, and no intranuclear virus like particles were found. Most striking was a pattern of proliferation of the endoplasmic reticulum associated with intracisternal filaments and particles. The possible relation of this cytoplasmic alteration to HB virus replication deserves further study.

Original languageEnglish (US)
Pages (from-to)373-379
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Issue number6
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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