TY - JOUR
T1 - Hemoglobin I in an American Negro family
T2 - Structural and hematologic studies
AU - Schneider, Rose G.
AU - Alperin, Jack B.
AU - Beale, Dennis
AU - Lehmann, Hermann
PY - 1966/12
Y1 - 1966/12
N2 - An American Negro family is described, in which the mother and two children have hemoglobin I trait, each with 24 to 28 per cent hemoglobin I. In all three of these subjects, target cells comprise about 10 per cent of the erythrocyte population. No other hematologic abnormality was found in the parents and their five examined children. In tests with 4 per cent sodium metabisulfite, changes resembling sickling occurred in the erythrocytes of all seven members of the family and also in five unrelated individuals who are homozygous for hemoglobin A. On structural analysis, the substitution in this sample of hemoglobin I is α16 lys → glu, as was previously found in one other sample of hemoglobin I (I Philadelphia).
AB - An American Negro family is described, in which the mother and two children have hemoglobin I trait, each with 24 to 28 per cent hemoglobin I. In all three of these subjects, target cells comprise about 10 per cent of the erythrocyte population. No other hematologic abnormality was found in the parents and their five examined children. In tests with 4 per cent sodium metabisulfite, changes resembling sickling occurred in the erythrocytes of all seven members of the family and also in five unrelated individuals who are homozygous for hemoglobin A. On structural analysis, the substitution in this sample of hemoglobin I is α16 lys → glu, as was previously found in one other sample of hemoglobin I (I Philadelphia).
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M3 - Article
C2 - 5926190
AN - SCOPUS:0013982872
SN - 0022-2143
VL - 68
SP - 940
EP - 946
JO - The Journal of Laboratory and Clinical Medicine
JF - The Journal of Laboratory and Clinical Medicine
IS - 6
ER -