Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway

Khosrow Siamak Houschyar; Mimi R. Borrelli; Susanne Rein; Christian Tapking; Daniel Popp; Alen Palackic; Behrus Puladi; Mark Ooms; Madeline Houschyar; Ludwik K. Branski; Laurenz Schmitt; Ali Modabber; Albert Rübben; Frank Hölzle; Amir S. Yazdi

doi:10.1007/s00238-022-01958-x

Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway

Khosrow Siamak Houschyar, Mimi R. Borrelli, Susanne Rein, Christian Tapking, Daniel Popp, Alen Palackic, Behrus Puladi, Mark Ooms, Madeline Houschyar, Ludwik K. Branski, Laurenz Schmitt, Ali Modabber, Albert Rübben, Frank Hölzle, Amir S. Yazdi

Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC. Level of evidence: Not gradable.

Original language	English (US)
Pages (from-to)	863-871
Number of pages	9
Journal	European Journal of Plastic Surgery
Volume	45
Issue number	6
DOIs	https://doi.org/10.1007/s00238-022-01958-x
State	Published - Dec 2022

Keywords

Carcinoma
Stem cells
Wnt signaling

ASJC Scopus subject areas

Surgery

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10.1007/s00238-022-01958-x

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Houschyar, K. S., Borrelli, M. R., Rein, S., Tapking, C., Popp, D., Palackic, A., Puladi, B., Ooms, M., Houschyar, M., Branski, L. K., Schmitt, L., Modabber, A., Rübben, A., Hölzle, F., & Yazdi, A. S. (2022). Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway. European Journal of Plastic Surgery, 45(6), 863-871. https://doi.org/10.1007/s00238-022-01958-x

Houschyar, KS, Borrelli, MR, Rein, S, Tapking, C, Popp, D, Palackic, A, Puladi, B, Ooms, M, Houschyar, M, Branski, LK, Schmitt, L, Modabber, A, Rübben, A, Hölzle, F & Yazdi, AS 2022, 'Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway', European Journal of Plastic Surgery, vol. 45, no. 6, pp. 863-871. https://doi.org/10.1007/s00238-022-01958-x

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title = "Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway",

abstract = "Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC. Level of evidence: Not gradable.",

keywords = "Carcinoma, Stem cells, Wnt signaling",

author = "Houschyar, {Khosrow Siamak} and Borrelli, {Mimi R.} and Susanne Rein and Christian Tapking and Daniel Popp and Alen Palackic and Behrus Puladi and Mark Ooms and Madeline Houschyar and Branski, {Ludwik K.} and Laurenz Schmitt and Ali Modabber and Albert R{\"u}bben and Frank H{\"o}lzle and Yazdi, {Amir S.}",

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year = "2022",

month = dec,

doi = "10.1007/s00238-022-01958-x",

language = "English (US)",

volume = "45",

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TY - JOUR

T1 - Head and neck squamous cell carcinoma

T2 - a potential therapeutic target for the Wnt signaling pathway

AU - Houschyar, Khosrow Siamak

AU - Borrelli, Mimi R.

AU - Rein, Susanne

AU - Tapking, Christian

AU - Popp, Daniel

AU - Palackic, Alen

AU - Puladi, Behrus

AU - Ooms, Mark

AU - Houschyar, Madeline

AU - Branski, Ludwik K.

AU - Schmitt, Laurenz

AU - Modabber, Ali

AU - Rübben, Albert

AU - Hölzle, Frank

AU - Yazdi, Amir S.

PY - 2022/12

Y1 - 2022/12

N2 - Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC. Level of evidence: Not gradable.

AB - Squamous cell carcinoma (SCC) of the head and neck region accounts for 3% of all tumors worldwide. The incidence is higher in men, with most carcinomas found in the oral cavity. At the point of initial diagnosis, distant metastases are rare. The Wnt signaling pathway is critically involved in cell development and stemness and has been associated with SCC. Understanding precisely how Wnt signaling regulates SCC progression and how it can, therefore, be modulated for the therapeutic benefit has enormous potential in the treatment of head and neck SCC. In this review, we will describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes both in homeostasis and in the development and progression of SCC. Level of evidence: Not gradable.

KW - Carcinoma

KW - Stem cells

KW - Wnt signaling

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U2 - 10.1007/s00238-022-01958-x

DO - 10.1007/s00238-022-01958-x

M3 - Review article

AN - SCOPUS:85128481585

SN - 0930-343X

VL - 45

SP - 863

EP - 871

JO - European Journal of Plastic Surgery

JF - European Journal of Plastic Surgery

IS - 6

ER -

Head and neck squamous cell carcinoma: a potential therapeutic target for the Wnt signaling pathway

Abstract

Keywords

ASJC Scopus subject areas

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