Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus

Silvana Levis; Jorge Garcia; Noemí Pini; Gladys Calderón; Josefina Ramírez; Daniel Bravo; Stephen St. Jeor; Carlos Ripoll; Mariana Bego; Elena Lozano; Rubén Barquez; Thomas G. Ksiazek; Delia Enria

doi:10.4269/ajtmh.2004.71.658

Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus

Silvana Levis, Jorge Garcia, Noemí Pini, Gladys Calderón, Josefina Ramírez, Daniel Bravo, Stephen St. Jeor, Carlos Ripoll, Mariana Bego, Elena Lozano, Rubén Barquez, Thomas G. Ksiazek, Delia Enria

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Orán viruses.

Original language	English (US)
Pages (from-to)	658-663
Number of pages	6
Journal	American Journal of Tropical Medicine and Hygiene
Volume	71
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.2004.71.658
State	Published - Nov 2004
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

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Levis, S., Garcia, J., Pini, N., Calderón, G., Ramírez, J., Bravo, D., St. Jeor, S., Ripoll, C., Bego, M., Lozano, E., Barquez, R., Ksiazek, T. G., & Enria, D. (2004). Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus. American Journal of Tropical Medicine and Hygiene, 71(5), 658-663. https://doi.org/10.4269/ajtmh.2004.71.658

Levis, S, Garcia, J, Pini, N, Calderón, G, Ramírez, J, Bravo, D, St. Jeor, S, Ripoll, C, Bego, M, Lozano, E, Barquez, R, Ksiazek, TG & Enria, D 2004, 'Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus', American Journal of Tropical Medicine and Hygiene, vol. 71, no. 5, pp. 658-663. https://doi.org/10.4269/ajtmh.2004.71.658

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abstract = "The purpose of this study was to characterize the hantaviruses circulating in northwestern Argentina. Human and rodent studies were conducted in Yuto, where most cases of hantavirus pulmonary syndrome (HPS) occur. Partial virus genome sequences were obtained from the blood of 12 cases of HPS, and from the lungs of 4 Calomys callosus and 1 Akodon simulator. Phylogenetic analysis showed that three genotypes associated with HPS circulate in Yuto. Laguna Negra (LN) virus, associated with C. laucha in Paraguay, was identified for the first time in Argentina; it was recovered from human cases and from C. callosus samples. The high sequence identity between human and rodent samples implicated C. callosus as the primary rodent reservoir for LN virus in Yuto. The genetic analysis showed that the Argentinian LN virus variant differed 16.8% at the nucleotide level and 2.9% at the protein level relative to the Paraguayan LN virus. The other two hantavirus lineages identified were the previously known Bermejo and Or{\'a}n viruses.",

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AU - Bego, Mariana

AU - Lozano, Elena

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Hantavirus pulmonary syndrome in northwestern Argentina: Circulation of Laguna Negra virus associated with Calomys callosus

Abstract

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