Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection

Zhilei Shan; Clary B. Clish; Simin Hua; Justin M. Scott; David B. Hanna; Robert D. Burk; Sabina A. Haberlen; Sanjiv J. Shah; Joseph B. Margolick; Cynthia L. Sears; Wendy S. Post; Alan L. Landay; Jason M. Lazar; Howard N. Hodis; Kathryn Anastos; Robert C. Kaplan; Qibin Qi

doi:10.1093/infdis/jiy356

Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection

Zhilei Shan, Clary B. Clish, Simin Hua, Justin M. Scott, David B. Hanna, Robert D. Burk, Sabina A. Haberlen, Sanjiv J. Shah, Joseph B. Margolick, Cynthia L. Sears, Wendy S. Post, Alan L. Landay, Jason M. Lazar, Howard N. Hodis, Kathryn Anastos, Robert C. Kaplan, Qibin Qi

Research output: Contribution to journal › Article › peer-review

Abstract

We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

Original language	English (US)
Pages (from-to)	1474-1479
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	218
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiy356
State	Published - Sep 22 2018
Externally published	Yes

Keywords

Carotid atherosclerosis
Choline metabolites
HIV infection
Risk factors
Trimethylamine-N-oxide

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiy356

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Shan, Z., Clish, C. B., Hua, S., Scott, J. M., Hanna, D. B., Burk, R. D., Haberlen, S. A., Shah, S. J., Margolick, J. B., Sears, C. L., Post, W. S., Landay, A. L., Lazar, J. M., Hodis, H. N., Anastos, K., Kaplan, R. C., & Qi, Q. (2018). Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection. Journal of Infectious Diseases, 218(9), 1474-1479. https://doi.org/10.1093/infdis/jiy356

Shan, Z, Clish, CB, Hua, S, Scott, JM, Hanna, DB, Burk, RD, Haberlen, SA, Shah, SJ, Margolick, JB, Sears, CL, Post, WS, Landay, AL, Lazar, JM, Hodis, HN, Anastos, K, Kaplan, RC & Qi, Q 2018, 'Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection', Journal of Infectious Diseases, vol. 218, no. 9, pp. 1474-1479. https://doi.org/10.1093/infdis/jiy356

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title = "Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection",

abstract = "We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.",

keywords = "Carotid atherosclerosis, Choline metabolites, HIV infection, Risk factors, Trimethylamine-N-oxide",

author = "Zhilei Shan and Clish, {Clary B.} and Simin Hua and Scott, {Justin M.} and Hanna, {David B.} and Burk, {Robert D.} and Haberlen, {Sabina A.} and Shah, {Sanjiv J.} and Margolick, {Joseph B.} and Sears, {Cynthia L.} and Post, {Wendy S.} and Landay, {Alan L.} and Lazar, {Jason M.} and Hodis, {Howard N.} and Kathryn Anastos and Kaplan, {Robert C.} and Qibin Qi",

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doi = "10.1093/infdis/jiy356",

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AU - Shan, Zhilei

AU - Clish, Clary B.

AU - Hua, Simin

AU - Scott, Justin M.

AU - Hanna, David B.

AU - Burk, Robert D.

AU - Haberlen, Sabina A.

AU - Shah, Sanjiv J.

AU - Margolick, Joseph B.

AU - Sears, Cynthia L.

AU - Post, Wendy S.

AU - Landay, Alan L.

AU - Lazar, Jason M.

AU - Hodis, Howard N.

AU - Anastos, Kathryn

AU - Kaplan, Robert C.

AU - Qi, Qibin

PY - 2018/9/22

Y1 - 2018/9/22

N2 - We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

AB - We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

KW - Carotid atherosclerosis

KW - Choline metabolites

KW - HIV infection

KW - Risk factors

KW - Trimethylamine-N-oxide

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Gut microbial-related choline metabolite trimethylamine-N-oxide is associated with progression of carotid artery atherosclerosis in HIV infection

Abstract

Keywords

ASJC Scopus subject areas

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