Guidelines for the long-term treatment of depression

R. M.A. Hirschfeld, C. B. Nemeroff, D. L. Dunner, C. B. Montano, C. L. DeVane

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Depression is frequently a recurrent and sometimes a chronic illness. Unfortunately, most research on treatment has focused almost exclusively on the short-term. For example, the majority of clinical trials of medications and psychotherapeutic approaches last only 6 to 16 weeks. Relatively little research has been conducted on continuation treatment (usually 3-6 months) to prevent relapses and on maintenance treatment (6-24 months) to prevent recurrences. This paper will review continuation and maintenance phase pharmacotherapeutic trials and will make recommendations for clinical treatment of patients during these periods.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalJournal of Clinical Psychiatry
Issue number12 SUPPL.
StatePublished - 1994

ASJC Scopus subject areas

  • Psychiatry and Mental health


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