Glutamine Kinetics in Burn Patients: Comparison With Hormonally Induced Stress in Volunteers

Dennis C. Gore; Farook Jahoor

doi:10.1001/archsurg.1994.01420360108015

Glutamine Kinetics in Burn Patients: Comparison With Hormonally Induced Stress in Volunteers

Dennis C. Gore, Farook Jahoor

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

These findings suggest that in the acute stress response, skeletal muscle preferentially releases glutamine from its free intracellular pool. As this reserve becomes depleted, net glutamine efflux is maintained by decreasing its rate of muscle glutamine utilization. These results suggest a failure of muscle to augment de novo glutamine synthesis and support the conclusion that glutamine is a conditionally essential amino acid during critical illness. (Arch Surg. 1994;129:1318-1323).

Original language	English (US)
Pages (from-to)	1318-1323
Number of pages	6
Journal	Archives of Surgery
Volume	129
Issue number	12
DOIs	https://doi.org/10.1001/archsurg.1994.01420360108015
State	Published - Dec 1994
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1994.01420360108015

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abstract = "These findings suggest that in the acute stress response, skeletal muscle preferentially releases glutamine from its free intracellular pool. As this reserve becomes depleted, net glutamine efflux is maintained by decreasing its rate of muscle glutamine utilization. These results suggest a failure of muscle to augment de novo glutamine synthesis and support the conclusion that glutamine is a conditionally essential amino acid during critical illness. (Arch Surg. 1994;129:1318-1323).",

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AB - These findings suggest that in the acute stress response, skeletal muscle preferentially releases glutamine from its free intracellular pool. As this reserve becomes depleted, net glutamine efflux is maintained by decreasing its rate of muscle glutamine utilization. These results suggest a failure of muscle to augment de novo glutamine synthesis and support the conclusion that glutamine is a conditionally essential amino acid during critical illness. (Arch Surg. 1994;129:1318-1323).

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Glutamine Kinetics in Burn Patients: Comparison With Hormonally Induced Stress in Volunteers

Abstract

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