TY - JOUR
T1 - Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050
AU - GBD 2019 MSK in Adolescents Collaborators
AU - Jin, Yingzhao
AU - Guo, Cui
AU - Abbasian, Mohammadreza
AU - Abbasifard, Mitra
AU - Abbott, J. Haxby
AU - Abdullahi, Auwal
AU - Abedi, Aidin
AU - Abidi, Hassan
AU - Abolhassani, Hassan
AU - Abu-Gharbieh, Eman
AU - Aburuz, Salahdein
AU - Abu-Zaid, Ahmed
AU - Addo, Isaac Yeboah
AU - Adegboye, Oyelola A.
AU - Adepoju, Abiola Victor
AU - Adikusuma, Wirawan
AU - Adnani, Qorinah Estiningtyas Sakilah
AU - Aghamiri, Shahin
AU - Ahmad, Danish
AU - Ahmed, Ayman
AU - Aithala, Janardhana P.
AU - Akhlaghi, Shiva
AU - Akkala, Sreelatha
AU - Alalwan, Tariq A.
AU - Albashtawy, Mohammed
AU - Alemi, Hediyeh
AU - Alhalaiqa, Fadwa Alhalaiqa Naji
AU - Ali, Endale Alemayehu
AU - Almustanyir, Sami
AU - Al-Raddadi, Rajaa M.
AU - Alvis-Zakzuk, Nelson J.
AU - Al-Worafi, Yaser Mohammed
AU - Alzahrani, Hosam
AU - Alzoubi, Karem H.
AU - Amiri, Sohrab
AU - Amu, Hubert
AU - Amzat, Jimoh
AU - Anderson, David B.
AU - Anil, Abhishek
AU - Antony, Benny
AU - Arabloo, Jalal
AU - Areda, Damelash
AU - Artaman, Al
AU - Artamonov, Anton A.
AU - Aryal, Krishna K.
AU - Asghari-Jafarabadi, Mohammad
AU - Ashraf, Tahira
AU - Athari, Seyyed Shamsadin
AU - Atinafu, Bantalem Tilaye
AU - Lee, Wei Chen
N1 - Publisher Copyright:
© 2024 The Author
PY - 2024/8/9
Y1 - 2024/8/9
N2 - Background: This study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. Methods: The global prevalence, years lived with disabilities (YLDs), disability-adjusted life years (DALYs), projection, and inequality were estimated for early MSK diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck pain (NP), gout, and other MSK diseases (OMSKDs). Findings: More adolescents and young adults were expected to develop MSK disorders by 2050. Across five age groups, the rates of prevalence, YLDs, and DALYs for RA, NP, LBP, gout, and OMSKDs sharply increased from ages 15–19 to 35–39; however, these were negligible for OA before age 30 but increased notably at ages 30–34, rising at least 6-fold by 35–39. The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. Conclusions: Multilevel interventions should be initiated to prevent disease burden related to RA, NP, LBP, gout, and OMSKDs among individuals ages 15–19 and to OA among individuals ages 30–34 to tightly control high BMI and kidney dysfunction. Funding: The Global Burden of Disease study is funded by the Bill and Melinda Gates Foundation. The project is funded by the Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38).
AB - Background: This study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. Methods: The global prevalence, years lived with disabilities (YLDs), disability-adjusted life years (DALYs), projection, and inequality were estimated for early MSK diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck pain (NP), gout, and other MSK diseases (OMSKDs). Findings: More adolescents and young adults were expected to develop MSK disorders by 2050. Across five age groups, the rates of prevalence, YLDs, and DALYs for RA, NP, LBP, gout, and OMSKDs sharply increased from ages 15–19 to 35–39; however, these were negligible for OA before age 30 but increased notably at ages 30–34, rising at least 6-fold by 35–39. The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. Conclusions: Multilevel interventions should be initiated to prevent disease burden related to RA, NP, LBP, gout, and OMSKDs among individuals ages 15–19 and to OA among individuals ages 30–34 to tightly control high BMI and kidney dysfunction. Funding: The Global Burden of Disease study is funded by the Bill and Melinda Gates Foundation. The project is funded by the Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38).
KW - Global Burden of Disease study
KW - Translation to population health
KW - gout
KW - inequality
KW - low back pain
KW - musculoskeletal disorders
KW - neck pain
KW - osteoarthritis
KW - pattern
KW - rheumatoid arthritis
KW - trend
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U2 - 10.1016/j.medj.2024.04.009
DO - 10.1016/j.medj.2024.04.009
M3 - Article
C2 - 38834074
AN - SCOPUS:85197097486
SN - 2666-6359
VL - 5
SP - 943-962.e6
JO - Med
JF - Med
IS - 8
ER -