Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid)

David W. Roberts, Pablo A. Valdés, Brent T. Harris, Alexander Hartov, Xiaoyao Fan, Songbai Ji, Frederic Leblond, Tor D. Tosteson, Brian C. Wilson, Keith D. Paulsen

Research output: Contribution to journalReview articlepeer-review


5-Aminolevulinic acid (5-ALA)-induced tumor fluorescence can be used to identify tissue for resection using an adapted operating microscope. A multi-institutional clinical trial comparing fluorescence-guided versus white light tumor resection reported significant improvement in completeness of resection and 6-month progression-free survival. The degree of 5-ALA-induced fluorescence correlates with histopathologic grade of tumor, degree of tumor cell infiltration, and proliferation indices. Quantitative methodologies for assessment of tissue fluorescence have significantly improved the ability to detect tumor tissue and intraoperative diagnostic performance. These developments extend the applicability of this technology to additional tumor histologies and provide the rationale for further instrumentation development.

Original languageEnglish (US)
Pages (from-to)371-377
Number of pages7
JournalNeurosurgery Clinics of North America
Issue number3
StatePublished - Jul 2012
Externally publishedYes


  • 5-ALA
  • Fluorescence
  • Glioma
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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