Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014

Maria N.B. Cajimat; Sergio E. Rodriguez; Isolde U.E. Schuster; Daniele Swetnam; Thomas G. Ksiazek; Miguel A. Habela; Ana Isabel Negredo; Agustín Estrada-Peña; Alan D.T. Barrett; Dennis A. Bente

doi:10.1089/vbz.2017.2190

Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014

Maria N.B. Cajimat, Sergio E. Rodriguez, Isolde U.E. Schuster, Daniele Swetnam, Thomas G. Ksiazek, Miguel A. Habela, Ana Isabel Negredo, Agustín Estrada-Peña, Alan D.T. Barrett, Dennis A. Bente

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from Cáceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in Cáceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.

Original language	English (US)
Pages (from-to)	714-719
Number of pages	6
Journal	Vector-Borne and Zoonotic Diseases
Volume	17
Issue number	10
DOIs	https://doi.org/10.1089/vbz.2017.2190
State	Published - Oct 2017

Keywords

Crimean-Congo hemorrhagic fever (CCHF)
Hyalomma tick
Spain
emerging disease
tick-borne disease

ASJC Scopus subject areas

Infectious Diseases
Virology
Microbiology

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title = "Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014",

abstract = "Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from C{\'a}ceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in C{\'a}ceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.",

keywords = "Crimean-Congo hemorrhagic fever (CCHF), Hyalomma tick, Spain, emerging disease, tick-borne disease",

author = "Cajimat, {Maria N.B.} and Rodriguez, {Sergio E.} and Schuster, {Isolde U.E.} and Daniele Swetnam and Ksiazek, {Thomas G.} and Habela, {Miguel A.} and Negredo, {Ana Isabel} and Agust{\'i}n Estrada-Pe{\~n}a and Barrett, {Alan D.T.} and Bente, {Dennis A.}",

year = "2017",

month = oct,

doi = "10.1089/vbz.2017.2190",

language = "English (US)",

volume = "17",

pages = "714--719",

journal = "Vector-Borne and Zoonotic Diseases",

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T1 - Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014

AU - Cajimat, Maria N.B.

AU - Rodriguez, Sergio E.

AU - Schuster, Isolde U.E.

AU - Swetnam, Daniele

AU - Ksiazek, Thomas G.

AU - Habela, Miguel A.

AU - Negredo, Ana Isabel

AU - Estrada-Peña, Agustín

AU - Barrett, Alan D.T.

AU - Bente, Dennis A.

PY - 2017/10

Y1 - 2017/10

N2 - Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from Cáceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in Cáceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.

AB - Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne disease caused by CCHF virus (CCHFV). Ticks in the genus Hyalomma are the main vectors and reservoirs of CCHFV. In Spain, CCHFV was first detected in Hyalomma ticks from Cáceres in 2010. Subsequently, two autochthonous CCHF cases were reported in August 2016. In this study, we describe the characterization of the CCHFV genome directly from Hyalomma lusitanicum collected in Cáceres in 2014. Phylogenetic analyses reveal a close relationship with clade III strains from West Africa, with an estimated divergence time of 50 years. The results of this work suggest that CCHFV has been circulating in Spain for some time, and most likely originated from West Africa.

KW - Crimean-Congo hemorrhagic fever (CCHF)

KW - Hyalomma tick

KW - Spain

KW - emerging disease

KW - tick-borne disease

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ER -

Genomic Characterization of Crimean-Congo Hemorrhagic Fever Virus in Hyalomma Tick from Spain, 2014

Abstract

Keywords

ASJC Scopus subject areas

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