Genomic and phylogenetic characterization of Leanyer virus, a novel orthobunyavirus isolated in northern Australia

Nazir Savji, Gustavo Palacios, Amelia Travassos da Rosa, Stephen Hutchison, Christopher Celone, Jeffrey Hui, Thomas Briese, Charles H. Calisher, Robert B. Tesh, W. Ian Lipkin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Leanyer virus (LEAV), currently classified as a member of the genus Orthobunyavirus, in the family Bunyaviridae, was originally isolated from a pool of Anopheles meraukensis mosquitoes, collected at Leanyer, Northern Territory, Australia in 1974. When it failed to react in serological tests with antisera from other known viruses, full-length genomic sequencing was pursued to determine the relationship of LEAV to other orthobunyavirus species. Genetic and serological characterization confirmed its antigenic distance from other orthobunyaviruses, including to its closest genetic neighbours, the Simbu group viruses, suggesting that it may represent a new antigenic complex.

Original languageEnglish (US)
Pages (from-to)1676-1687
Number of pages12
JournalJournal of General Virology
Volume92
Issue number7
DOIs
StatePublished - Jul 2011
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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