Genome sequence diversity and clues to the evolution of variola (smallpox) virus

Joseph J. Esposito, Scott A. Sammons, A. Michael Frace, John D. Osborne, Melissa Glsen-Rasmussen, Ming Zhang, Dhwani Govil, Inger K. Damon, Richard Kline, Miriam Laker, Yu Li, Geoffrey L. Smith, Hermann Meyer, James W. LeDuc, Robert M. Wohlhueter

Research output: Contribution to journalArticlepeer-review

119 Scopus citations


Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content. Phylogenetic clustering inferred three clades coincident with their geographical origin and case-fatality rate; the latter implicated putative proteins that mediate viral virulence differences. Analysis of the viral linear DNA genome suggests that its evolution involved direct descent and DNA end-region recombination events. Knowing the sequences will help understand the viral proteome and improve diagnostic test precision, therapeutics, and systems for their assessment.

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
Issue number5788
StatePublished - Aug 11 2006
Externally publishedYes

ASJC Scopus subject areas

  • General


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