Abstract
We have previously cloned two mouse homeobox genes Tlx-1 (T-cell leukemia homeobox gene-1) and a related gene Tlx-2 based on their homology to human HOX11, a putative proto-oncogene involved in human T-cell leukemia. We have mapped Tlx-1 to mouse chromosome 19 and Tlx-2 to chromosome 6 by linkage analysis using an interspecific backcross (C57BL/6J × Mus spretus) F1 × M. spretus. The proposed gene orders and genetic distances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4-(5.32 cM)-Tlx-1-(3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tcrb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 388-390 |
| Number of pages | 3 |
| Journal | Genomics |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 15 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics