@article{5fa637e2a9bf4e09b5f8405858d846e2,
title = "Genetic diversity among Bolivian arenaviruses",
abstract = "Machupo virus and Chapare virus are members of the Tacaribe serocomplex (virus family Arenaviridae) and etiological agents of hemorrhagic fever in humans in Bolivia. The nucleotide sequences of the complete Z genes, a large fragment of the RNA-dependent RNA polymerase genes, the complete glycoprotein precursor genes, and the complete nucleocapsid protein genes of 8 strains of Machupo virus were determined to increase our knowledge of the genetic diversity among the Bolivian arenaviruses. The results of analyses of the predicted amino acid sequences of the glycoproteins of the Machupo virus strains and Chapare virus strain 200001071 indicated that immune plasma from hemorrhagic fever cases caused by Machupo virus may prove beneficial in the treatment of Bolivian hemorrhagic fever but not hemorrhagic fever caused by Chapare virus.",
keywords = "Arenaviridae, Bolivian hemorrhagic fever, Chapare virus, Latino virus, Machupo virus",
author = "Cajimat, {Maria N.B.} and Milazzo, {Mary Louise} and Rollin, {Pierre E.} and Nichol, {Stuart T.} and Bowen, {Michael D.} and Ksiazek, {Thomas G.} and Fulhorst, {Charles F.}",
note = "Funding Information: Mary Louise Milazzo and Maria N.B. Cajimat contributed equally to this study. Craig Manning (Centers for Disease Control and Prevention, National Center for Zoonotic, Viral, and Enteric Diseases) constructed the map in Fig. 1 . Laura K. McMullan, Michelle Vanoy, and Heather L. Wurtzel (Centers for Disease Control and Prevention, National Center for Infectious Diseases) determined the nucleocapsid protein gene sequences listed in Table 1 . Natalie A. Dodsley-Prow (The University of Texas Medical Branch at Galveston) assisted with the characterization of the small genomic segments of MACV strains Chicava, MARU 216606, MARU 222688, MARU 249121, 9301012, 9430084, and 200002427. National Institutes of Health grant AI-53428 (“Rapid, accurate diagnostic assays for arenaviral infections”) provided financial support for this study. A Presidential Leave Award from John D. Stobo (President, The University of Texas Medical Branch at Galveston) provided salary for Charles F. Fulhorst while he worked on this study at the Centers for Disease Control and Prevention in Atlanta, GA.",
year = "2009",
month = mar,
doi = "10.1016/j.virusres.2008.10.016",
language = "English (US)",
volume = "140",
pages = "24--31",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier",
number = "1-2",
}