TY - JOUR
T1 - Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia
AU - Lokugamage, Kumari
AU - Kariwa, Hiroaki
AU - Hayasaka, Daisuke
AU - Cui, Bai Zhong
AU - Iwasaki, Takuya
AU - Lokugamage, Nandadeva
AU - Ivanov, Leonid I.
AU - Volkov, Vladimir I.
AU - Demenev, Vladimir A.
AU - Slonova, Raisa
AU - Kompanets, Galina
AU - Kushnaryova, Tatyana
AU - Kurata, Takeshi
AU - Maeda, Kenji
AU - Araki, Koichi
AU - Mizutani, Tetsuya
AU - Yoshimatsu, Kumiko
AU - Arikawa, Jiro
AU - Takashima, Ikuo
PY - 2002/8
Y1 - 2002/8
N2 - In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.
AB - In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.
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U2 - 10.3201/eid0808.010494
DO - 10.3201/eid0808.010494
M3 - Article
C2 - 12141960
AN - SCOPUS:0036687345
SN - 1080-6040
VL - 8
SP - 768
EP - 776
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 8
ER -