GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Jack T. Stapleton; Jeffrey A. Martinson; Donna Klinzman; Jinhua Xiang; Seema N. Desai; Alan Landay

doi:10.1097/QAD.0b013e328363089f

GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Jack T. Stapleton, Jeffrey A. Martinson, Donna Klinzman, Jinhua Xiang, Seema N. Desai, Alan Landay

Research output: Contribution to journal › Article › peer-review

Abstract

GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

Original language	English (US)
Pages (from-to)	1829-1832
Number of pages	4
Journal	AIDS
Volume	27
Issue number	11
DOIs	https://doi.org/10.1097/QAD.0b013e328363089f
State	Published - Jul 17 2013
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/QAD.0b013e328363089f

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title = "GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals",

abstract = "GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.",

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AU - Stapleton, Jack T.

AU - Martinson, Jeffrey A.

AU - Klinzman, Donna

AU - Xiang, Jinhua

AU - Desai, Seema N.

AU - Landay, Alan

PY - 2013/7/17

Y1 - 2013/7/17

N2 - GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

AB - GB virus C (GBV-C), a pan-lymphotropic flavivirus capable of persistent infection, is associated with prolonged survival and reduced T-cell activation in HIV-infected patients. GBV-C was associated with reduced CD56brt/CD16 natural killer cell and monocyte activation, and a trend toward reduced B-cell activation by measuring cell surface activation markers or HIV entry coreceptors. The GBV-C association was independent of HIV viral load. Thus, GBV-C may influence non-T-cell immune activation in individuals with HIV infection.

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AN - SCOPUS:84879853448

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ER -

GB virus C infection and B-cell, natural killer cell, and monocyte activation markers in HIV-infected individuals

Abstract

ASJC Scopus subject areas

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