Fungal sepsis: An increasing problem in major thermal injuries

J. M. Pensler, D. N. Herndon, H. Ptak, E. Bonds, T. C. Rutan, M. H. Desai, S. Abston

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


In major thermal burns there has been an alarming emergence of fungal sepsis as defined by involvement of three or more organs and/or repeated positive blood cultures. During an 18-month period, we treated 72 patients (aged 18 ± 2 years; TBSA burn, 57 ± 3%; percent of third-degree bum, 45 ± 3) with fungal sepsis. In all patients with documented three-organ involvement, treatment was with intravenous amphotericin (0.5 mg/kg body weight/day), immediate wound debridement, and early wound closure. The mortality was 32% (23 patients); 49 (68%) survived infection. Sixty-two variables were reviewed retrospectively using multiple regression analysis to ascertain specific factors associated with fungal sepsis and their relationship to survival. In burn patients, fungal sepsis is a strong determinant of survival, and its occurrence overshadows traditional factors presently utilized to predict clinical outcome.

Original languageEnglish (US)
Pages (from-to)488-491
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Issue number6
StatePublished - 1986

ASJC Scopus subject areas

  • Surgery
  • General Nursing
  • Emergency Medicine
  • Rehabilitation
  • General Health Professions


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