Functional Consequences of the Somatopause and its Treatment

Andrew R. Hoffman, Steven A. Lieberman, Gail Butterfield, Janice Thompson, Raymond L. Hintz, Gian Paolo Ceda, Robert Marcus

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
Issue number1
StatePublished - 1997
Externally publishedYes


  • Body composition
  • GH
  • IGF-I
  • Somatopause

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Functional Consequences of the Somatopause and its Treatment'. Together they form a unique fingerprint.

Cite this