Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes

Sandra L. Wong; Celia Chao; Michael J. Edwards; David J. Carlson; Alison Laidley; R. Dirk Noyes; Terre McGlothin; Philip B. Ley; Todd Tuttle; Mark Schadt; Robert Pennington; Mary Legenza; James Morgan; Kelly M. McMasters; Edward Clifford; Tom White; Suzanne Klimberg

doi:10.1016/S0002-9610(02)01057-7

Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes

Sandra L. Wong, Celia Chao, Michael J. Edwards, David J. Carlson, Alison Laidley, R. Dirk Noyes, Terre McGlothin, Philip B. Ley, Todd Tuttle, Mark Schadt, Robert Pennington, Mary Legenza, James Morgan, Kelly M. McMasters, Edward Clifford, Tom White, Suzanne Klimberg

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Background: The need for axillary nodal staging in favorable histologic subtypes of breast cancer is controversial. Methods: Patients with clinical stage T1-2, N0 breast cancer were enrolled in a prospective, multi-institutional study. All patients underwent sentinel lymph node (SLN) biopsy followed by completion level I/II axillary dissection. Results: SLN were identified in 3,106 of 3,324 patients (93%). Axillary metastases were found in 35% and 40% of patients with infiltrating ductal carcinoma and infiltrating lobular carcinoma, respectively. Among tumor subtypes, positive nodes were found in 17% of patients with pure tubular carcinoma, 7% of patients with papillary cancer, 6% of patients with colloid (mucinous) carcinoma, 21% of patients with medullary carcinoma, and 8% of patients with DCIS with microinvasion. Conclusions: Patients with favorable breast cancer subtypes have a significant rate of axillary nodal metastasis. Axillary nodal staging remains important in such patients; SLN biopsy is an ideal method to obtain this staging information.

Original language	English (US)
Pages (from-to)	492-498
Number of pages	7
Journal	American Journal of Surgery
Volume	184
Issue number	6
DOIs	https://doi.org/10.1016/S0002-9610(02)01057-7
State	Published - Dec 1 2002
Externally published	Yes

Keywords

Axillary lymph node dissection
Breast cancer
Pathology
Sentinel node biopsy

ASJC Scopus subject areas

Surgery

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10.1016/S0002-9610(02)01057-7

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Wong, S. L., Chao, C., Edwards, M. J., Carlson, D. J., Laidley, A., Noyes, R. D., McGlothin, T., Ley, P. B., Tuttle, T., Schadt, M., Pennington, R., Legenza, M., Morgan, J., McMasters, K. M., Clifford, E., White, T., & Klimberg, S. (2002). Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes. American Journal of Surgery, 184(6), 492-498. https://doi.org/10.1016/S0002-9610(02)01057-7

Wong, SL, Chao, C, Edwards, MJ, Carlson, DJ, Laidley, A, Noyes, RD, McGlothin, T, Ley, PB, Tuttle, T, Schadt, M, Pennington, R, Legenza, M, Morgan, J, McMasters, KM, Clifford, E, White, T & Klimberg, S 2002, 'Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes', American Journal of Surgery, vol. 184, no. 6, pp. 492-498. https://doi.org/10.1016/S0002-9610(02)01057-7

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title = "Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes",

abstract = "Background: The need for axillary nodal staging in favorable histologic subtypes of breast cancer is controversial. Methods: Patients with clinical stage T1-2, N0 breast cancer were enrolled in a prospective, multi-institutional study. All patients underwent sentinel lymph node (SLN) biopsy followed by completion level I/II axillary dissection. Results: SLN were identified in 3,106 of 3,324 patients (93%). Axillary metastases were found in 35% and 40% of patients with infiltrating ductal carcinoma and infiltrating lobular carcinoma, respectively. Among tumor subtypes, positive nodes were found in 17% of patients with pure tubular carcinoma, 7% of patients with papillary cancer, 6% of patients with colloid (mucinous) carcinoma, 21% of patients with medullary carcinoma, and 8% of patients with DCIS with microinvasion. Conclusions: Patients with favorable breast cancer subtypes have a significant rate of axillary nodal metastasis. Axillary nodal staging remains important in such patients; SLN biopsy is an ideal method to obtain this staging information.",

keywords = "Axillary lymph node dissection, Breast cancer, Pathology, Sentinel node biopsy",

author = "Wong, {Sandra L.} and Celia Chao and Edwards, {Michael J.} and Carlson, {David J.} and Alison Laidley and Noyes, {R. Dirk} and Terre McGlothin and Ley, {Philip B.} and Todd Tuttle and Mark Schadt and Robert Pennington and Mary Legenza and James Morgan and McMasters, {Kelly M.} and Edward Clifford and Tom White and Suzanne Klimberg",

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doi = "10.1016/S0002-9610(02)01057-7",

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T1 - Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes

AU - Wong, Sandra L.

AU - Chao, Celia

AU - Edwards, Michael J.

AU - Carlson, David J.

AU - Laidley, Alison

AU - Noyes, R. Dirk

AU - McGlothin, Terre

AU - Ley, Philip B.

AU - Tuttle, Todd

AU - Schadt, Mark

AU - Pennington, Robert

AU - Legenza, Mary

AU - Morgan, James

AU - McMasters, Kelly M.

AU - Clifford, Edward

AU - White, Tom

AU - Klimberg, Suzanne

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Background: The need for axillary nodal staging in favorable histologic subtypes of breast cancer is controversial. Methods: Patients with clinical stage T1-2, N0 breast cancer were enrolled in a prospective, multi-institutional study. All patients underwent sentinel lymph node (SLN) biopsy followed by completion level I/II axillary dissection. Results: SLN were identified in 3,106 of 3,324 patients (93%). Axillary metastases were found in 35% and 40% of patients with infiltrating ductal carcinoma and infiltrating lobular carcinoma, respectively. Among tumor subtypes, positive nodes were found in 17% of patients with pure tubular carcinoma, 7% of patients with papillary cancer, 6% of patients with colloid (mucinous) carcinoma, 21% of patients with medullary carcinoma, and 8% of patients with DCIS with microinvasion. Conclusions: Patients with favorable breast cancer subtypes have a significant rate of axillary nodal metastasis. Axillary nodal staging remains important in such patients; SLN biopsy is an ideal method to obtain this staging information.

AB - Background: The need for axillary nodal staging in favorable histologic subtypes of breast cancer is controversial. Methods: Patients with clinical stage T1-2, N0 breast cancer were enrolled in a prospective, multi-institutional study. All patients underwent sentinel lymph node (SLN) biopsy followed by completion level I/II axillary dissection. Results: SLN were identified in 3,106 of 3,324 patients (93%). Axillary metastases were found in 35% and 40% of patients with infiltrating ductal carcinoma and infiltrating lobular carcinoma, respectively. Among tumor subtypes, positive nodes were found in 17% of patients with pure tubular carcinoma, 7% of patients with papillary cancer, 6% of patients with colloid (mucinous) carcinoma, 21% of patients with medullary carcinoma, and 8% of patients with DCIS with microinvasion. Conclusions: Patients with favorable breast cancer subtypes have a significant rate of axillary nodal metastasis. Axillary nodal staging remains important in such patients; SLN biopsy is an ideal method to obtain this staging information.

KW - Axillary lymph node dissection

KW - Breast cancer

KW - Pathology

KW - Sentinel node biopsy

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Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes

Abstract

Keywords

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