Fractional flow reserve using computed tomography for assessing coronary artery disease: A meta-analysis

Hemang B. Panchal, Sreenivas P. Veeranki, Samit Bhatheja, Neil Barry, Ehtisham Mahmud, Matthew Budoff, Steven J. Lavine, Hadii M. Mamudu, Timir K. Paul

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations


    Aims: Noninvasive fractional flow reserve (FFR) measurement with computed tomography (FFRCT) is a newly described method for assessing functional significance of coronary disease. The objective of this metaanalysis is to determine the diagnostic performance of FFRCTin the assessment of hemodynamically significant coronary artery stenosis. Methods: PubMed and the Cochrane Center Register of Controlled Trials were searched from January 2000 through February 2015. Six original studies were found comparing FFRCTto invasive FFR in evaluating hemodynamic significance of coronary lesions (1354 vessels; 812 patients). Lesions were considered hemodynamically significant if invasive FFR was 0.80 or less. FFRCTused the same cutoff as invasive FFR to be considered as a positive test. Sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio were calculated. Results: One-third of the lesions (n=443) were hemodynamically significant. The pooled per-vessel analysis showed that the sensitivity, specificity, negative and positive likelihood ratios, and diagnostic odds ratio of FFRCTto diagnose hemodynamically significant coronary disease were 0.84 [95% confidence interval (CI):0.80-0.87], 0.76 (95% CI: 0.73-0.79), 0.22 (95% CI: 0.17-0.29), 3.48 (95% CI: 2.21-5.47), and 16.82 (95% CI: 8.20-34.49), respectively. Conclusion: The results of this meta-analysis demonstrate that FFRCTresults correlate closely with invasive coronary angiography and FFR measurement. It is a feasible noninvasive method to assess hemodynamic significance of coronary lesions in patients with stable coronary artery disease.

    Original languageEnglish (US)
    Pages (from-to)694-700
    Number of pages7
    JournalJournal of Cardiovascular Medicine
    Issue number9
    StatePublished - 2016


    • Computed tomography angiography
    • Coronary artery lesion
    • Diagnostic accuracy
    • Fractional flow reserve

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine


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