TY - JOUR
T1 - Forces on adhesive contacts affect cell function
AU - Galbraith, Catherine G.
AU - Sheetz, Michael P.
PY - 1998/10
Y1 - 1998/10
N2 - Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.
AB - Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.
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U2 - 10.1016/S0955-0674(98)80030-6
DO - 10.1016/S0955-0674(98)80030-6
M3 - Article
C2 - 9818165
AN - SCOPUS:0031671026
SN - 0955-0674
VL - 10
SP - 566
EP - 571
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -