Fluorescence probe for cervical examination during various reproductive states

Wenling S. Glassman, Qin Ping Liao, Shao Qing Shi, Linda Goodrum, Gayle Olson, Elizabeth Martin, George Saade, Robert E. Garfield

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations


These studies represent further investigations that have been done utilizing the fluorescence from pyridinoline, one of the major crosslinks of type I and III collagen, to evaluate cervical connective tissue changes during various female reproductive periods. Based on our previous studies, a prototype instrument has been constructed. The instrument was specifically designed for the purpose of vaginal examination of cervical connective tissue by measuring light induced fluorescence directly from the surface of the external os of the cervix. The studies were carried out on nonpregnant rats, rats during gestation at different periods, rats at different times during postpartum, and rats during preterm birth after being treated with antiprogesterone drugs. A study has also been done on humans during pregnancy and postpartum. The results parallel previous investigations that have used various invasive methods to analyze cervical extensibility, cervical collagen content and collagenase. In consideration of the important role of the collagen fibers and their turnover in the process of cervical function during pregnancy (softening or ripening at term), this method could be a useful tool for evaluating treatment strategies of the cervix. Moreover, the instrument could serve as a device for the non-invasive estimation of cervical status in the clinic and the diagnosis of the changes in the cervix during the preparation for labor.

Original languageEnglish (US)
Pages (from-to)286-292
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1997
EventAdvances in Fluorescence Sensing Technology III - San Jose, CA, United States
Duration: Feb 9 1997Feb 9 1997


  • Cervix
  • Clinic examination
  • Collagen
  • Dilation
  • Fluorescence spectroscopy
  • Pregnancy
  • Pyridinoline

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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