Flea-borne rickettsioses in the north of caldas province, Colombia

Marylin Hidalgo; Viviana Montoya; Alejandra Martínez; Marcela Mercado; Alberto De La Ossa; Carolina Vélez; Gloria Estrada; Jorge E. Pérez; Alvaro A. Faccini-Martínez; Marcelo B. Labruna; Gustavo Valbuena

doi:10.1089/vbz.2012.1173

Flea-borne rickettsioses in the north of caldas province, Colombia

Marylin Hidalgo, Viviana Montoya, Alejandra Martínez, Marcela Mercado, Alberto De La Ossa, Carolina Vélez, Gloria Estrada, Jorge E. Pérez, Alvaro A. Faccini-Martínez, Marcelo B. Labruna, Gustavo Valbuena

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Rickettsia typhi and R. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. Both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. In 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of Caldas, Colombia. We now report the specific seroprevalence against R. typhi and R. felis, and associated risk factors in 7 towns of this province. The combined seroprevalence against the 2 flea-borne rickettsioses is the highest yet reported in the literature: 71.7% (17.8% for R. felis, 25.2% for R. typhi, and 28.7% for both). We also report a prospective analysis of 26 patients with a febrile illness compatible with rickettsioses, including murine typhus; 9 of these patients had a rickettsiosis. This supports our sero-epidemiological results and highlights the diagnostic complexity of febrile syndromes in this region.

Original language	English (US)
Pages (from-to)	289-294
Number of pages	6
Journal	Vector-Borne and Zoonotic Diseases
Volume	13
Issue number	5
DOIs	https://doi.org/10.1089/vbz.2012.1173
State	Published - 2013
Externally published	Yes

Keywords

Colombia
Fleas
Rickettsia
Rickettsia felis
Zoonotic diseases.

ASJC Scopus subject areas

Microbiology
Infectious Diseases
Virology

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10.1089/vbz.2012.1173

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title = "Flea-borne rickettsioses in the north of caldas province, Colombia",

abstract = "Rickettsia typhi and R. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. Both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. In 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of Caldas, Colombia. We now report the specific seroprevalence against R. typhi and R. felis, and associated risk factors in 7 towns of this province. The combined seroprevalence against the 2 flea-borne rickettsioses is the highest yet reported in the literature: 71.7% (17.8% for R. felis, 25.2% for R. typhi, and 28.7% for both). We also report a prospective analysis of 26 patients with a febrile illness compatible with rickettsioses, including murine typhus; 9 of these patients had a rickettsiosis. This supports our sero-epidemiological results and highlights the diagnostic complexity of febrile syndromes in this region.",

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author = "Marylin Hidalgo and Viviana Montoya and Alejandra Mart{\'i}nez and Marcela Mercado and {De La Ossa}, Alberto and Carolina V{\'e}lez and Gloria Estrada and P{\'e}rez, {Jorge E.} and Faccini-Mart{\'i}nez, {Alvaro A.} and Labruna, {Marcelo B.} and Gustavo Valbuena",

year = "2013",

doi = "10.1089/vbz.2012.1173",

language = "English (US)",

volume = "13",

pages = "289--294",

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issn = "1530-3667",

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T1 - Flea-borne rickettsioses in the north of caldas province, Colombia

AU - Hidalgo, Marylin

AU - Montoya, Viviana

AU - Martínez, Alejandra

AU - Mercado, Marcela

AU - De La Ossa, Alberto

AU - Vélez, Carolina

AU - Estrada, Gloria

AU - Pérez, Jorge E.

AU - Faccini-Martínez, Alvaro A.

AU - Labruna, Marcelo B.

AU - Valbuena, Gustavo

PY - 2013

Y1 - 2013

N2 - Rickettsia typhi and R. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. Both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. In 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of Caldas, Colombia. We now report the specific seroprevalence against R. typhi and R. felis, and associated risk factors in 7 towns of this province. The combined seroprevalence against the 2 flea-borne rickettsioses is the highest yet reported in the literature: 71.7% (17.8% for R. felis, 25.2% for R. typhi, and 28.7% for both). We also report a prospective analysis of 26 patients with a febrile illness compatible with rickettsioses, including murine typhus; 9 of these patients had a rickettsiosis. This supports our sero-epidemiological results and highlights the diagnostic complexity of febrile syndromes in this region.

AB - Rickettsia typhi and R. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. Both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. In 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of Caldas, Colombia. We now report the specific seroprevalence against R. typhi and R. felis, and associated risk factors in 7 towns of this province. The combined seroprevalence against the 2 flea-borne rickettsioses is the highest yet reported in the literature: 71.7% (17.8% for R. felis, 25.2% for R. typhi, and 28.7% for both). We also report a prospective analysis of 26 patients with a febrile illness compatible with rickettsioses, including murine typhus; 9 of these patients had a rickettsiosis. This supports our sero-epidemiological results and highlights the diagnostic complexity of febrile syndromes in this region.

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KW - Rickettsia

KW - Rickettsia felis

KW - Zoonotic diseases.

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Flea-borne rickettsioses in the north of caldas province, Colombia

Abstract

Keywords

ASJC Scopus subject areas

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