TY - JOUR
T1 - Flavivirus RNA transactions from viral entry to genome replication
AU - Garcia-Blanco, Mariano A.
AU - Vasudevan, Subhash G.
AU - Bradrick, Shelton S.
AU - Nicchitta, Christopher
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Upon release of the ∼11 kb single-stranded positive polarity dengue virus genomic RNA (gRNA) into the cytoplasm of an infected cell, it serves as the template for translation of the viral polyprotein, which is cleaved into three structural and seven non-structural proteins. The structural organization of the viral replication complex and RNA is not known but it is increasingly becoming evident that the viral gRNA and replication intermediates adopt unique structural features and localize to discrete regions in the infected cell. Both structure and location play multiple roles ranging from evasion of innate immune response to recruitment of viral and host proteins for translation and replication of the message. This review visits the various transactions that the viral gRNA undergoes between entry and RNA synthesis with the view that some of these events may be targeted by antiviral compounds. This article forms part of a symposium on flavivirus drug discovery in Antiviral Research.
AB - Upon release of the ∼11 kb single-stranded positive polarity dengue virus genomic RNA (gRNA) into the cytoplasm of an infected cell, it serves as the template for translation of the viral polyprotein, which is cleaved into three structural and seven non-structural proteins. The structural organization of the viral replication complex and RNA is not known but it is increasingly becoming evident that the viral gRNA and replication intermediates adopt unique structural features and localize to discrete regions in the infected cell. Both structure and location play multiple roles ranging from evasion of innate immune response to recruitment of viral and host proteins for translation and replication of the message. This review visits the various transactions that the viral gRNA undergoes between entry and RNA synthesis with the view that some of these events may be targeted by antiviral compounds. This article forms part of a symposium on flavivirus drug discovery in Antiviral Research.
KW - Dengue RNA replication
KW - Dengue RNA structure
KW - Dengue RNA translation
KW - Dengue genomic RNA
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U2 - 10.1016/j.antiviral.2016.09.010
DO - 10.1016/j.antiviral.2016.09.010
M3 - Review article
C2 - 27666184
AN - SCOPUS:84990033455
SN - 0166-3542
VL - 134
SP - 244
EP - 249
JO - Antiviral research
JF - Antiviral research
ER -