Flavivirus NS5 prevents the InSTATement of IFN

Pei Yong Shi

doi:10.1016/j.chom.2014.08.011

Flavivirus NS5 prevents the InSTATement of IFN

Pei Yong Shi

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Given the potency of interferon-α/β, viral evasion of this pathway is crucial for infection. In this issue of Cell Host & Microbe, Laurent-Rolle et al. (2014) report that during yellow fever virus infection, interferon-α/β stimulates the polyubiquitination of viral NS5, which binds to STAT2 and inhibits transcription of interferon-stimulated genes.

Original language	English (US)
Pages (from-to)	269-271
Number of pages	3
Journal	Cell Host and Microbe
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2014.08.011
State	Published - Sep 10 2014
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2014.08.011

Cite this

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title = "Flavivirus NS5 prevents the InSTATement of IFN",

abstract = "Given the potency of interferon-α/β, viral evasion of this pathway is crucial for infection. In this issue of Cell Host & Microbe, Laurent-Rolle et al. (2014) report that during yellow fever virus infection, interferon-α/β stimulates the polyubiquitination of viral NS5, which binds to STAT2 and inhibits transcription of interferon-stimulated genes.",

author = "Shi, {Pei Yong}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = sep,

day = "10",

doi = "10.1016/j.chom.2014.08.011",

language = "English (US)",

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T1 - Flavivirus NS5 prevents the InSTATement of IFN

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PY - 2014/9/10

Y1 - 2014/9/10

N2 - Given the potency of interferon-α/β, viral evasion of this pathway is crucial for infection. In this issue of Cell Host & Microbe, Laurent-Rolle et al. (2014) report that during yellow fever virus infection, interferon-α/β stimulates the polyubiquitination of viral NS5, which binds to STAT2 and inhibits transcription of interferon-stimulated genes.

AB - Given the potency of interferon-α/β, viral evasion of this pathway is crucial for infection. In this issue of Cell Host & Microbe, Laurent-Rolle et al. (2014) report that during yellow fever virus infection, interferon-α/β stimulates the polyubiquitination of viral NS5, which binds to STAT2 and inhibits transcription of interferon-stimulated genes.

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U2 - 10.1016/j.chom.2014.08.011

DO - 10.1016/j.chom.2014.08.011

M3 - Short survey

C2 - 25211068

AN - SCOPUS:84907700836

SN - 1931-3128

VL - 16

SP - 269

EP - 271

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 3

ER -

Flavivirus NS5 prevents the InSTATement of IFN

Abstract

ASJC Scopus subject areas

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