Flavivirus infection associated with cerebrovascular events

Cássia F. Estofolete, Bruno H.G.A. Milhim, Nathalia Zini, Samuel N. Scamardi, Joana D.Arc Selvante, Nikos Vasilakis, Maurício L. Nogueira

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Arthropod-borne viruses (arboviruses) of the genus Flavivirus are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, São Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Louis encephalitis viruses. Our findings highlight the potential threat that unusual clinical manifestations may pose to arbovirus disease management and recovery.

Original languageEnglish (US)
Article number671
Issue number6
StatePublished - Jun 2020


  • Atypical manifestations
  • Cerebrovascular events
  • Dengue virus
  • Zika virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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