Family history of dementia predicts worse neuropsychological functioning among HIV-infected persons

David J. Moore, Miguel Arce, Suzanne Moseley, J. Allen Mccutchan, Jennifer Marquie-Beck, Donald R. Franklin, Florin Vaida, Cristian L. Achim, Justin Mcarthur, Susan Morgello, David M. Simpson, Benjamin B. Gelman, Ann C. Collier, Christina M. Marra, David B. Clifford, Robert K. Heaton, Igor Grant

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


HIV-negative individuals with a family history of dementia (FHD) are more likely to develop dementia than those without FHD. Whether FHD increases risk for neuropsychological (NP) impairment in HIV+ persons is unknown. As part of a multisite study into HIV-associated neurocognitive disorders (HAND), the authors captured FHD with a free-response, self-report question, and assessed NP performance with a comprehensive battery of tests. The authors examined HIV+ persons with (N=190) and without (N=916) self-reported FHD. Despite the fact that the FHD group had factors typically associated with better NP performance (e.g., higher CD4 counts and estimated verbal IQ), persons with FHD had significantly worse NP ability than those without FHD as measured by a Global Deficit Score. Thus, FHD appears to be a risk factor for HAND; the mechanism(s) underlying how FHD contributes to NP impairment among HIV+ persons warrants study.

Original languageEnglish (US)
Pages (from-to)316-323
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
StatePublished - 2011

ASJC Scopus subject areas

  • General Medicine


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