Extensively drug-resistant acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

Noor Zaidan; J. Patrik Hornak; David Reynoso

doi:10.1128/AAC.00924-21

Extensively drug-resistant acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

Noor Zaidan, J. Patrik Hornak, David Reynoso

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Extremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.

Original language	English (US)
Article number	e00924-21
Journal	Antimicrobial agents and chemotherapy
Volume	65
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00924-21
State	Published - Nov 2021

Keywords

Acinetobacter baumanii
Antibiotic resistance
Antimicrobial agents
Beta-lactamases
Beta-lactams
Durlobactam
Gram-negative bacteria
Gram-negative resistance
Nosocomial infections
Novel antibiotics
Sulbactam-durlobactam

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00924-21

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title = "Extensively drug-resistant acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination",

abstract = "Extremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.",

keywords = "Acinetobacter baumanii, Antibiotic resistance, Antimicrobial agents, Beta-lactamases, Beta-lactams, Durlobactam, Gram-negative bacteria, Gram-negative resistance, Nosocomial infections, Novel antibiotics, Sulbactam-durlobactam",

author = "Noor Zaidan and Hornak, {J. Patrik} and David Reynoso",

year = "2021",

month = nov,

doi = "10.1128/AAC.00924-21",

language = "English (US)",

volume = "65",

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publisher = "American Society for Microbiology",

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AU - Hornak, J. Patrik

AU - Reynoso, David

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N2 - Extremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.

AB - Extremely drug-resistant (XDR) Acinetobacter baumannii causes challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.

KW - Acinetobacter baumanii

KW - Antibiotic resistance

KW - Antimicrobial agents

KW - Beta-lactamases

KW - Beta-lactams

KW - Durlobactam

KW - Gram-negative bacteria

KW - Gram-negative resistance

KW - Nosocomial infections

KW - Novel antibiotics

KW - Sulbactam-durlobactam

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JO - Antimicrobial agents and chemotherapy

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IS - 11

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ER -

Extensively drug-resistant acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

Abstract

Keywords

ASJC Scopus subject areas

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