Exposure to inhomogeneous static magnetic field beneficially affects allergic inflammation in a murine model

Anikó Csillag, Brahma V. Kumar, Krisztina Szabó, Mária Szilasi, Zsuzsa Papp, Magdolna E. Szilasi, Kitti Pázmándi, István Boldogh, Éva Rajnavölgyi, Attila Bácsi, János F. László

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Previous observations suggest that static magnetic field (SMF)-exposure acts on living organisms partly through reactive oxygen species (ROS) reactions. In this study, we aimed to define the impact of SMF-exposure on ragweed pollen extract (RWPE)-induced allergic inflammation closely associated with oxidative stress. Inhomogeneous SMF was generated with an apparatus validated previously providing a peak-to-peak magnetic induction of the dominant SMF component 389 mT by 39 T m-1 lateral gradient in the in vivo and in vitro experiments, and 192 mT by 19 T m-1 in the human study at the 3 mm target distance. Effects of SMF-exposure were studied in a murine model of allergic inflammation and also in human provoked skin allergy.We found that even a single 30-min exposure of mice to SMF immediately following intranasal RWPE challenge significantly lowered the increase in the total antioxidant capacity of the airways and decreased allergic inflammation. Repeated (on 3 consecutive days) or prolonged (60 min) exposure to SMF after RWPE challenge decreased the severity of allergic responses more efficiently than a single 30-min treatment. SMF-exposure did not alter ROS production by RWPE under cell-free conditions, while diminished RWPE-induced increase in the ROS levels in A549 epithelial cells. Results of the human skin prick tests indicated that SMF-exposure had no significant direct effect on provoked mast cell degranulation. The observed beneficial effects of SMF are likely owing to the mobilization of cellular ROS-eliminating mechanisms rather than direct modulation of ROS production by pollen NAD(P)H oxidases.

Original languageEnglish (US)
Article number20140097
JournalJournal of the Royal Society Interface
Issue number95
StatePublished - Jun 6 2014


  • Allergic inflammation
  • Oxidative stress
  • Pollen
  • Static magnetic field

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering


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