TY - JOUR
T1 - Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
AU - de Souza, William Marciel
AU - Machado, Alex Martins
AU - Figueiredo, Luiz Tadeu Moraes
N1 - Publisher Copyright:
© 2016, Fundacao Oswaldo Cruz. All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.
AB - This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.
KW - Experimental infection
KW - Rio Mamore hantavirus
KW - Wild Sigmodontinae rodents
UR - http://www.scopus.com/inward/record.url?scp=84971401670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971401670&partnerID=8YFLogxK
U2 - 10.1590/0074-02760160021
DO - 10.1590/0074-02760160021
M3 - Article
C2 - 27223653
AN - SCOPUS:84971401670
SN - 0074-0276
VL - 111
SP - 399
EP - 402
JO - Memorias do Instituto Oswaldo Cruz
JF - Memorias do Instituto Oswaldo Cruz
IS - 6
ER -