TY - JOUR
T1 - Expanding the physiological role of the hexameric DnaB helicase
AU - Bujalowski, Wlodzimierz
N1 - Funding Information:
This work was supported by NIH Grant GM–46679.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.
AB - The hexameric DnaB protein is the Escherichia coli primary replicative helicase. However, recent studies indicate that this enzyme is capable of driving branch migration of a Holliday junction, acting more like an ATP-driven pump than a helicase. This offers an attractive possibility that the protein is directly involved in DNA recombination in vivo. Thus, the physiological role of the DnaB protein in DNA metabolism, and its modes of action, might be more complex than previously thought.
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U2 - 10.1016/S0968-0004(03)00034-3
DO - 10.1016/S0968-0004(03)00034-3
M3 - Short survey
C2 - 12633988
AN - SCOPUS:0037333742
SN - 0968-0004
VL - 28
SP - 116
EP - 118
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 3
ER -