Evolution of SARS-CoV-2 virus and assessment of the effectiveness of COVID-19 vaccine

Veljko Veljkovic; Vladimir Perovic; Isabelle Chambers; Slobodan Paessler

doi:10.12688/F1000RESEARCH.28215.1

Evolution of SARS-CoV-2 virus and assessment of the effectiveness of COVID-19 vaccine

Veljko Veljkovic, Vladimir Perovic, Isabelle Chambers, Slobodan Paessler

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARSCoV- 2 represents the principal target for most vaccines currently under development. Despite the presence of a CoV proof-reading function in viral replication, SP protein from SARS-CoV still extensively mutates, which might have an impact on current and future vaccine development. Here, we present analysis of more than 1600 SP unique variants suggesting that vaccine candidates based on the Wuhan-Hu-1 reference strain would be effective against most of currently circulated SARS-CoV-2 viruses, but that further monitoring of the evolution of this virus is important for identification of other mutations, which could affect the effectiveness of vaccines.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	F1000Research
Volume	10
DOIs	https://doi.org/10.12688/F1000RESEARCH.28215.1
State	Published - 2021

Keywords

COVID-19
SARS-CoV-2
mutations
vaccine effectiveness

ASJC Scopus subject areas

General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.12688/F1000RESEARCH.28215.1

Cite this

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abstract = "A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARSCoV- 2 represents the principal target for most vaccines currently under development. Despite the presence of a CoV proof-reading function in viral replication, SP protein from SARS-CoV still extensively mutates, which might have an impact on current and future vaccine development. Here, we present analysis of more than 1600 SP unique variants suggesting that vaccine candidates based on the Wuhan-Hu-1 reference strain would be effective against most of currently circulated SARS-CoV-2 viruses, but that further monitoring of the evolution of this virus is important for identification of other mutations, which could affect the effectiveness of vaccines.",

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AU - Veljkovic, Veljko

AU - Perovic, Vladimir

AU - Chambers, Isabelle

AU - Paessler, Slobodan

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AB - A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARSCoV- 2 represents the principal target for most vaccines currently under development. Despite the presence of a CoV proof-reading function in viral replication, SP protein from SARS-CoV still extensively mutates, which might have an impact on current and future vaccine development. Here, we present analysis of more than 1600 SP unique variants suggesting that vaccine candidates based on the Wuhan-Hu-1 reference strain would be effective against most of currently circulated SARS-CoV-2 viruses, but that further monitoring of the evolution of this virus is important for identification of other mutations, which could affect the effectiveness of vaccines.

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Evolution of SARS-CoV-2 virus and assessment of the effectiveness of COVID-19 vaccine

Abstract

Keywords

ASJC Scopus subject areas

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