Evolution of SARS-CoV-2 virus and assessment of the effectiveness of COVID-19 vaccine

Veljko Veljkovic, Vladimir Perovic, Isabelle Chambers, Slobodan Paessler

Research output: Contribution to journalArticlepeer-review


A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARSCoV- 2 represents the principal target for most vaccines currently under development. Despite the presence of a CoV proof-reading function in viral replication, SP protein from SARS-CoV still extensively mutates, which might have an impact on current and future vaccine development. Here, we present analysis of more than 1600 SP unique variants suggesting that vaccine candidates based on the Wuhan-Hu-1 reference strain would be effective against most of currently circulated SARS-CoV-2 viruses, but that further monitoring of the evolution of this virus is important for identification of other mutations, which could affect the effectiveness of vaccines.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
StatePublished - 2021


  • COVID-19
  • SARS-CoV-2
  • mutations
  • vaccine effectiveness

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology


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