Evolution of new genotype of west nile virus in North America

Allison R. McMullen; Fiona J. May; Li Li; Hilda Guzman; Rudy Bueno; James A. Dennett; Robert B. Tesh; Alan D.T. Barrett

doi:10.3201/eid1705.101707

Evolution of new genotype of west nile virus in North America

Allison R. McMullen, Fiona J. May, Li Li, Hilda Guzman, Rudy Bueno, James A. Dennett, Robert B. Tesh, Alan D.T. Barrett

Pathology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Previous studies of North American isolates of West Nile virus (WNV) during 1999-2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002-2009 suggests that this is not the case. Three new genetic groups have been identifi ed in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World.

Original language	English (US)
Pages (from-to)	785-793
Number of pages	9
Journal	Emerging infectious diseases
Volume	17
Issue number	5
DOIs	https://doi.org/10.3201/eid1705.101707
State	Published - 2011

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Evolution of new genotype of west nile virus in North America",

abstract = "Previous studies of North American isolates of West Nile virus (WNV) during 1999-2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002-2009 suggests that this is not the case. Three new genetic groups have been identifi ed in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World.",

author = "McMullen, {Allison R.} and May, {Fiona J.} and Li Li and Hilda Guzman and Rudy Bueno and Dennett, {James A.} and Tesh, {Robert B.} and Barrett, {Alan D.T.}",

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language = "English (US)",

volume = "17",

pages = "785--793",

journal = "Emerging infectious diseases",

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publisher = "Centers for Disease Control and Prevention (CDC)",

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T1 - Evolution of new genotype of west nile virus in North America

AU - McMullen, Allison R.

AU - May, Fiona J.

AU - Li, Li

AU - Guzman, Hilda

AU - Bueno, Rudy

AU - Dennett, James A.

AU - Tesh, Robert B.

AU - Barrett, Alan D.T.

PY - 2011

Y1 - 2011

N2 - Previous studies of North American isolates of West Nile virus (WNV) during 1999-2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002-2009 suggests that this is not the case. Three new genetic groups have been identifi ed in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World.

AB - Previous studies of North American isolates of West Nile virus (WNV) during 1999-2005 suggested that the virus had reached genetic homeostasis in North America. However, genomic sequencing of WNV isolates from Harris County, Texas, during 2002-2009 suggests that this is not the case. Three new genetic groups have been identifi ed in Texas since 2005. Spread of the southwestern US genotype (SW/WN03) from the Arizona/Colorado/northern Mexico region to California, Illinois, New Mexico, New York, North Dakota, and the Texas Gulf Coast demonstrates continued evolution of WNV. Thus, WNV continues to evolve in North America, as demonstrated by selection of this new genotype. Continued surveillance of the virus is essential as it continues to evolve in the New World.

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Evolution of new genotype of west nile virus in North America

Abstract

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