Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

Gerald A. Campbell; Michael J. Eckardt; Edward Majchrowicz; Cheryl A. Marietta; Forrest F. Weight

doi:10.1016/0006-8993(82)90465-6

Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

Gerald A. Campbell, Michael J. Eckardt, Edward Majchrowicz, Cheryl A. Marietta, Forrest F. Weight

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[¹⁴C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.

Original language	English (US)
Pages (from-to)	517-522
Number of pages	6
Journal	Brain Research
Volume	237
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)90465-6
State	Published - Apr 15 1982
Externally published	Yes

Keywords

2-deoxyglucose
ethanol-withdrawal syndrome

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(82)90465-6

Cite this

@article{ab1c5b4c0596434e98673b8d750f41ba,

title = "Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain",

abstract = "Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.",

keywords = "2-deoxyglucose, ethanol-withdrawal syndrome",

author = "Campbell, {Gerald A.} and Eckardt, {Michael J.} and Edward Majchrowicz and Marietta, {Cheryl A.} and Weight, {Forrest F.}",

year = "1982",

month = apr,

day = "15",

doi = "10.1016/0006-8993(82)90465-6",

language = "English (US)",

volume = "237",

pages = "517--522",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

AU - Campbell, Gerald A.

AU - Eckardt, Michael J.

AU - Majchrowicz, Edward

AU - Marietta, Cheryl A.

AU - Weight, Forrest F.

PY - 1982/4/15

Y1 - 1982/4/15

N2 - Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.

AB - Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.

KW - 2-deoxyglucose

KW - ethanol-withdrawal syndrome

UR - http://www.scopus.com/inward/record.url?scp=0020025143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020025143&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(82)90465-6

DO - 10.1016/0006-8993(82)90465-6

M3 - Article

C2 - 7200823

AN - SCOPUS:0020025143

SN - 0006-8993

VL - 237

SP - 517

EP - 522

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this