Endurance training attenuates the decrease in skeletal muscle malonyl- CoA with exercise

C. Adrian Hutber, B. B. Rasmussen, W. W. Winder

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Muscle malonyl-CoA has been postulated to regulate fatty acid metabolism by inhibiting carnitine palmitoyltransferase 1. In nontrained rats, malonyl- CoA decreases in working muscle during exercise. Endurance training is known to increase a muscle's reliance on fatty acids as a substrate. This study was designed to investigate whether the decline in malonyl-CoA with exercise would be greater in trained than in nontrained muscle, thereby allowing increased fatty acid oxidation. After 6-10 wk of endurance training (2 h/day) or treadmill habituation (5-10 min/day), rats were killed at rest or after running up a 15% grade at 21 m/min for 5, 20, or 60 min. Training attenuated the exercise induced drop in malonyl-CoA and prevented the exercise induced increase in the constant for citrate activation of acetyl-CoA carboxylase in the red quadriceps muscle of rats run for 20 and 60 min. Hence, contrary to expectations, the decrease in malonyl-CoA was less in trained than in non- trained muscle during a single bout of prolonged submaximal exercise.

Original languageEnglish (US)
Pages (from-to)1917-1922
Number of pages6
JournalJournal of Applied Physiology
Issue number6
StatePublished - Dec 1997
Externally publishedYes


  • Carnitine palmitoyltransferase
  • Fatty acid oxidation
  • Muscle acetyl-CoA carboxylase

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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