Endovascular thrombectomy for pediatric acute ischemic stroke: A multi-institutional experience of technical and clinical outcomes

Vijay M. Ravindra, Matthew Alexander, Philipp Taussky, Robert J. Bollo, Ameer E. Hassan, Jonathan P. Scoville, Julius Griauzde, Al Wala Awad, Mouhammad Jumaa, Syed Zaidi, Jonathan J. Lee, Muhammad Ubaid Hafeez, Fábio A. Nascimento, Melissa A. LoPresti, William T. Couldwell, Steven W. Hetts, Sandi K. Lam, Peter Kan, Ramesh Grandhi

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Endovascular thrombectomy is a promising treatment for acute ischemic stroke in children, but outcome and technical data in pediatric patients with large-vessel occlusions are lacking. OBJECTIVE: To assess technical and clinical outcomes of thrombectomy in pediatric patients. METHODS: We undertook a retrospective cohort study of pediatric patients who experienced acute ischemic stroke from April 2017 to April 2019 who had immediate, 30-, and 90-d follow-up. Patients were treated with endovascular thrombectomy at 5 US pediatric tertiary care facilities. We recorded initial and postprocedural modified Thrombolysis in Cerebral Infarction (mTICI) grade ≥ 2b, initial and postprocedural Pediatric National Institutes of Health Stroke Scale (PedNIHSS) score, and pediatric modified Rankin scale (mRS) score 0 to 2 at 90 d. RESULTS: There were 23 thrombectomies in 21 patients (mean age 11.6 ± 4.9 yr, median 11.5, range 2.1-19; 52% female). A total of 19 (83%) thrombectomies resulted in mTICI grade ≥ 2b recanalization. The median PedNIHSS score was 13 on presentation (range 4-33) and 2 (range 0-26) at discharge (mean reduction 11.3 ± 6.1). A total of 14 (66%) patients had a mRS score of 0 to 2 at 30-d follow-up; 18/21 (86%) achieved that by 90 d. The median mRS was 1 (range 0-4) at 30 d and 1 (range 0-5) at 90 d. One patient required a blood transfusion after thrombectomy. CONCLUSION: In this large series of pediatric patients treated with endovascular thrombectomy, successful recanalization was accomplished via a variety of approaches with excellent clinical outcomes; further prospective longitudinal study is needed.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
Issue number1
StatePublished - Jan 1 2021
Externally publishedYes


  • Anticoagulation
  • Cerebrovascular
  • Endovascular
  • Ischemic stroke
  • Pediatrics
  • Thrombectomy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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