Endothelial function and the regulation of muscle protein anabolism in older adults

K. L. Timmerman, E. Volpi

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Sarcopenia, the loss of skeletal muscle mass and function with aging, is a major contributor to frailty and morbidity in older adults. Recent evidence has emerged suggesting that endothelial dysfunction and insulin resistance of muscle protein metabolism may significantly contribute to the development of sarcopenia. In this article we review: 1) recent studies and theories on the regulation of skeletal muscle protein balance in older adults; 2) the linkbetween insulin resistance of muscle protein synthesis and endothelial dysfunction in aging; 3) mechanisms for impaired endothelial responsiveness in aging; and 4) potential treatments that may restore the endothelial responsiveness and muscle protein anabolic sensitivity in older adults.

Original languageEnglish (US)
Pages (from-to)S44eS50
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue numberSUPPL1
StatePublished - 2013


  • Endothelial dysfunction
  • Insulin resistance
  • Muscle protein metabolism
  • Sarcopenia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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