Endocrine control of body composition in infancy, childhood, and puberty

Johannes D. Veldhuis, James N. Roemmich, Erick J. Richmond, Alan D. Rogol, Jennifer C. Lovejoy, Melinda Sheffield-Moore, Nelly Mauras, Cyril Y. Bowers

Research output: Contribution to journalReview articlepeer-review

293 Scopus citations


Body composition exhibits marked variations across the early human lifetime. The precise physiological mechanisms that drive such developmental adaptations are difficult to establish. This clinical challenge reflects an array of potentially confounding factors, such as marked intersubject differences in tissue compartments; the incremental nature of longitudinal intrasubject variations in body composition; technical limitations in quantitating the unobserved mass of mineral, fat, water, and muscle ad seriatim; and the multifold contributions of genetic, dietary, environmental, hormonal, nutritional, and behavioral signals to physical and sexual maturation. From an endocrine perspective (reviewed here), gonadal sex steroids and GH/IGF-I constitute prime determinants of evolving body composition. The present critical review examines hormonal regulation of body composition in infancy, childhood, and puberty.

Original languageEnglish (US)
Pages (from-to)114-146
Number of pages33
JournalEndocrine Reviews
Issue number1
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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